"but as a setup point of view "
Technically, you can reproduce the same behaviour in an alloy wheel with a variety of offsets and thicknesses.
However, since it is often thickness, varying the stiffness, that is required rather than strength, one adopts the same techniques as in composite construction, one adds a lightweight core.
Putting a lightweight core into a kart wheel would be pretty difficult in metal, so we do the next best thing, alloy the metal with something lightweight, magnesium.
The fact that magnesium brings certain other qualities to the alloy is something with which one has to work.
So it isn't really a case of which metal your wheels are made of, but the design and shape and response. If you want a particular response, then you need a particular shape and that shape determines what material the wheel is made from.
How much research and knowledge goes into specifying the wheels is a different matter, just as I guess few purchasers look for the extra 0.5mm of thickness just there that should give them a different performance. (Just as there are many drivers who go out with front pressure and rear pressures rather than something different in each tyre.)
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